Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures. It can occur due to prolonged administration of propofol (an anesthetic) in mechanically …

Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:

Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol.

Mechanism of PRIS High doses of propofol (greater than 3mg/kg/h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic …

Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease.

Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures. …

If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated. General measures to support cardiac and renal function should be initiated promptly in patients with …

Propofol-related infusion syndrome (PRIS) is a rare but potentially fatal complication in critically ill patients. It is generally associated with high propofol doses and/or prolonged propofol administration …

May 13, 2021 · Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990. It is characterized by profound metabolic acidosis and bradycardia …

Propofol is widely used to sedate agitated patients in intensive care units. However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS). The pathophysiology of PRIS is …